Monica Nguyễn was born in Hanoi, Vietnam. She began violin lessons at the age of five and entered the Hanoi Academy at the age of nine to study violin. She received her Bachelor of Music degree from the Hanoi conservatory of music with distinction. In 1990 she won Third prize in the Autumn Violin Competition in Vietnam. In 1992 she was selected for a full scholarship to study at the Hong Kong Academy for Performing Arts and performed with the Hong Kong Sinfonietta upon graduation. She joined the City Chamber Orchestra of Hong Kong in 2008.